Authorities have not disclosed the identity of the deceased or passengers.
“There are planes everywhere,” Fire Chief Assistant Dan Eddie said in the scenes the authorities faced.
“As you can imagine, something very big at that amount of speed would have many throws that go in all directions,” he explained.
Earlier on Thursday, he confirmed he was “deeply hit by multiple homes” and that he couldn't believe anyone in those homes were seriously injured.
Footage from the scene shows burnt cars scattered across the street.
Local resident Christopher Moore told The Associated Press that he and his wife woke up loudly early in the morning.
Moore said they looked out the window and saw the smoke, and the couple grabbed their two young children and ran away.
Once they reached the street, they saw the car engulfed in flames.
“It was certainly scary, but sometimes you have to drop your head and get to safety,” Moore said.
A Marine who lives near the crash site told Fox News that he heard “a strange shit noise” and that “a boom and a shaking at home” continued.
The aircraft appeared to be heading towards Montgomery Field, an airport located 10 km (6 miles) north of downtown San Diego.
